The present study analytically, reflectively, and critically details the approach that Colombian authors José Asunción Silva, María Mercedes Carranza, Carlos Obregón, and dariolemos, as well as Ecuadorians Dolores Veintimilla de Galindo, Medardo Ángel Silva, Arturo Borja, Ernesto Noboa Caamaño, and César Dávila Andrade take on the theme of suicide through their literary work and how they respond to different complexities of the individual or to particular contexts and moments. For this approach, the conceptual, scientific, literary, and sociological references that some scholars advance on this thematic axis are considered, helping to clarify and better understand the notions and perceptions of the poets selected for the corpus. Additionally, studies on the life, death, and artistic legacy of these literary figures will serve as a basis for estimating the critical, historical, literary, and socio-political significance of these poets' perceptions regarding the concept of suicide, from both adjacent and underlying concepts, leading to various conclusions focused on the human and the literary.